Stats for PMx

Basic Concepts

• Effective Visual Communication for the Quantitative Scientist by M Vandemeulebroecke et al.

• Model Evaluation of Continuous Data Pharmacometric Models: Metrics and Graphics by THT Nguyen et al.

• Power Determination During Drug Development: Is Optimizing the Sample Size Based on Exposure-Response Analyses Underutilized? by AK Jones et al.

• Tutorial for $DESIGN in NONMEM: Clinical trial evaluation and optimization. by Bauer RJ et al.

• Confidence and Prediction Intervals for Pharmacometric Models by A Kümmel et al.

• Applied Statistics course by Penn State’s Department of Statistics

Logistic Regression

• Logistic Regression: A Brief Primer by the Society for Academic Emergency Medicine

• Applied Statistics course - Logistic Regression by Penn State’s Department of Statistics

• Logit Regression - R Data Analysis Examples by UCLA Statistical Consulting Group

Time to Event Analysis

• Brief introduction to parametric time to event model by Lim HS

• A Time to Event Tutorial for Pharmacometricians by Nick Holford

• Finding the right hazard function for time-to-event modeling: A tutorial and Shiny application by Rob C et al.

• Tutorial in biostatistics methods for interval-censored data by Lindsey JC and LM Ryan

• Statistical Methods - Proportional Hazards Regression by Penn State’s Department of Statistics

• An Overview of Joint Modeling of Longitudinal and Time to Event Data by Luke Fostvedt

Model-Based Meta-Analysis

• The Many Flavors of Model-Based Meta-Analysis: Part I-Introduction and Landmark Data by M Boucher and M Bennetts

• Many Flavors of Model-Based Meta-Analysis: Part II - Modeling Summary Level Longitudinal Responses by M Boucher and M Bennetts

• Applications of Model-Based Meta-Analysis in Drug Development by Phyllis C et. al. 

• Direct Oral Anticoagulants Vs. Enoxaparin for Prevention of Venous Thromboembolism Following Orthopedic Surgery: A Dose–Response Meta‐analysisby Boyd RA et. al. 

• Quantitative Evaluations of Time-Course and Treatment Effects of Systemic Agents for Psoriasis: A Model-Based Meta-Analysis by Checchio T et. al. 

• Model-based meta-analysis of non-small cell lung cancer with standard of care PD-1 inhibitors and chemotherapy for early development decision making by Turner DC et al. 

Bayesian Statistics

• Simple Bayesian analysis in clinical trials: a tutorial by Abrams K et al.

• Flexible and efficient Bayesian pharmacometrics modeling using Stan and Torsten, Part I by Margossian CC et al.

• Bayesian Workflow for PMx Analyses:

Latent Variable Modeling

• Exploring heterogeneity in clinical trials with latent class analysis by Zhang Z et al.

Covariate Modeling

• Efficient and relevant stepwise covariate model building for pharmacometrics by Svensson RJ and Jonsson EN

• The lasso–a novel method for predictive covariate model building in nonlinear mixed effects models by Ribbing J et al.

Delayed Differential Equation Models

• Delay differential equations based models in NONMEM by Yan X et al.

Case Studies

• Model-Based Discovery and Development of Biopharmaceuticals: A Case Study of Mavrilimumab by Bing Wang et al.

• Understanding the Behavior of Systems Pharmacology Models Using Mathematical Analysis of Differential Equations: Prolactin Modeling as a Case Study by S Bakshiet al.